OECD 439 - Bioscience Labs
1765 South 19th Ave Bozeman, MT    
877-858-2754

OECD 439

OECD 439

In-Vitro Skin Irritation: Reconstructed Human Epidermis Test Method

This method is based on the reconstructed human epidermis, which closely mimics the properties of the upper layers of the human skin. Cell viability is measured by enzymatic conversion of the vital dye MTT into a blue formazan salt that is quantitatively measured after extraction from tissues. Irritant test substances are identified by their ability to decrease cell viability below-defined threshold levels. This procedure may be used to determine the skin irritancy of test substances as a stand-alone replacement test for in vivo skin irritation testing, or as a partial replacement test, within a tiered testing strategy.

Labs

Labs


In-Vitro Testing Laboratory

Scientists in our In-Vitro testing labs are well trained on ASTM, AATCC, AOAC, CLSI and EN standard methods. The efficacy testing services of this laboratory include MIC/MBC, ...

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