In-Vitro Testing Laboratory - Bioscience Labs
1765 South 19th Ave Bozeman, MT    
877-858-2754

In-Vitro Testing Laboratory

In-Vitro Testing Laboratory

Scientists in our In-Vitro testing labs are well trained on ASTM, AATCC, AOAC, CLSI and EN standard methods. The efficacy testing services of this laboratory include MIC/MBC, biofilm prevention and removal, time-kill kinetics, cleanroom disinfectant validation, the zone of inhibition and custom efficacy studies for disinfectants, antimicrobials and other products requiring EPA registrations and FDA 510(k) submissions. Studies in our in-vitro lab can also be designed and executed to differentiate existing products within the market and support unique label claims.

BioScience provides a wide scope of in-vitro test evaluation possibilities from one to two microorganism screening evaluations to evaluations using more than 1,500 ATCC strains and clinical isolates.

Our In-Vitro Laboratory uses tissue models prepared by the company leading the development of alternatives to animal testing methods to perform safety testing on cosmetics, surfactant-based products, pharmaceuticals, and chemicals as well as products for personal care, hair care, and household cleaning. These tests include Ocular Irritation, Skin Irritation, Dermal Corrosion, Oral Irritation, and Cytotoxicity.

Services Include:

Methods

Services

Methods


AATCC

The American Association of Textile Chemists and Colorist (AATCC), is an internationally recognized association that provides testing methods for testing fibers and fabrics to...

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AATCC - 100

Antimicrobial Finishes on Textile Materials This test method provides a quantitative procedure for the evaluation of the degree of antibacterial activity. Assessment of antiba...

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AOAC

AOAC International is the independent science-based solutions through the development of microbiological and chemical standards. AOAC standards are used globally to facilitate...

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AOAC Germicidal Towelette Test

This standard method evaluates the efficacy of towelette disinfectants according to ASTM E2362-09 based on EPA SOP’s. BioScience Labs offers this service to provide the data y...

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AOAC 955.14, 955.15, and 964.02

Use Dilution Method These standard methods test the efficacy of disinfectants against three standard bacteria on hard surfaces. These standard tests are used for products in t...

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AOAC 955.16

Chlorine (available) in Disinfectants; Germicidal Equivalent Concentration This standard test method provides efficacy data that demonstrates the equivalent performance of Te...

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AOAC 955.17

Fungicidal activity of Disinfectants' Using Trichophyton Mentagrophytes This standard test method recommended by the EPA provides efficacy data for Test Products designed as d...

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AOAC 960.09

Germicidal and Detergent Sanitizing Action of Disinfectants Test This standard test method tests the efficacy of food contact sanitizers against S. aureus and E. coli. These s...

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AOAC 961.02

Germicidal Spray Products as Disinfectants This standard test method recommended by the EPA provides efficacy data for Test Products designed as germicidal spray products. The...

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AOAC 965.12

Tuberculocidal Activity of Disinfectants This standard test method recommended by the EPA demonstrates efficacy on hard non-porous surfaces against M. bovis. BioScience Labs o...

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AOAC 965.13

Disinfectants (Water) for Swimming Pools This standard test method recommended by the EPA provides efficacy data for Test Products designed to disinfect spa and pool water. Bi...

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AOAC 966.04

This standard method tests the efficacy of disinfectants against spore-forming bacteria on hard surface carriers. This standard test is suitable for determining sporicidal act...

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ASTM

These are among the most commonly used ASTM methods, please note that these are not our only capabilities. After discussing your needs with our experts, we are able to purchas...

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ASTM - E2647

Drip Flow Reactor Protocol BioScience Labs provides services for evaluating product efficacy in the prevention and/or removal of biofilms using in-vitro techniques. This metho...

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ASTM - E2799

MBEC Reactor Protocol BioScience Labs provides services for evaluating product efficacy in the prevention and/or removal of biofilms using in-vitro techniques. This method ser...

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ASTM - E2562

CDC Biofilm Reactor Protocol BioScience Labs provides services for evaluation of product efficacy in the prevention and/or removal of biofilms using in-vitro techniques. This ...

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ASTM - E2406

Standard Test Method for Evaluation of Laundry Sanitizers and Disinfectants for Use in High-Efficiency Washing Operations This test method is designed to evaluate sanitizing/d...

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ASTM - E2274

Standard Test Method for Evaluation of Laundry Sanitizers and Disinfectants This test method is designed to evaluate sanitizing/disinfectant laundry detergents/additives for u...

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ASTM - E2362

Standard Practice for Evaluation of Pre-saturated or Impregnated Towelettes for Hard Surface Disinfection This test method may be used to determine if a pre-saturated or impre...

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ASTM - E2149

Standard Test Method for Determining the Antimicrobial Activity of Antimicrobial Agents Under Dynamic Contact Conditions This test method is designed to evaluate the antimicro...

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ASTM - E2783

Standard Test Method for Assessment of Antimicrobial Activity for Water-Miscible Compounds Using a Time-Kill Procedure This test method measures the changes of a population of...

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ASTM - E1054

Standard Test Method for Evaluation of Inactivators of Antimicrobial Agents The effectiveness of antimicrobial agents incorporated into disinfectants, sanitizers, and antisept...

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ASTM - E1153

Standard Test Method for Efficacy of Sanitizers Recommended for Inanimate Non-Food Contact Surfaces This test method is used to evaluate the antimicrobial efficacy of sanitize...

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ASTM - E2197

Standard Quantitative Disk Carrier Test Method for Determining Bactericidal, Virucidal, Fungicidal, Mycobactericidal, and Sporicidal Activities of Chemicals This test method i...

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ASTM - E640

Standard Test Method for Preservatives in Water-Containing Cosmetics This test method covers the determination of the suitability of preservatives for use in cosmetic formulat...

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ASTM - E2280

Standard Test Method for Determining the Activity of Incorporated Antimicrobial Agent(s) In Polymeric or Hydrophobic Materials This test method is designed to evaluate (quanti...

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CLSI

The Clinical and Laboratory Standards Institute (CLSI) develops globally recognized clinical testing standards....

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CLSI M07-A10

Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically Susceptibility testing is indicated for any organism that contributes to an infectio...

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USP

The U.S Pharmacopoeia Convention (USP) is a scientific organization that sets standards for products distributed and consumed worldwide. These standards are used in many count...

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USP - 51

ANTIMICROBIAL PRESERVATIVE EFFECTIVENESS TEST (PET) The U.S. Pharmacopeia describes in General Chapter 51, the assay they recommend for testing preservative efficacy. The USP ...

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EN

European Standard (EN) are documents that globally recognized that define best practices and requirements for test-methods. This is a list of BSLI’s most commonly practiced EN...

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EN 14348

Quantitative Suspension Test for the Evaluation of Mycobactericidal Activity of Chemical Disinfectants in the Medical Area Including Instrument Disinfectants This document sp...

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EN 13624

Quantitative Suspension Test for the Evaluation of Fungicidal Activity of Chemical Disinfectants for Instruments used in the Medical Area This European Standard applies to pro...

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EN 13727

Quantitative Suspension Test for the Evaluation of Bactericidal Activity in the Medical Area This European Standard applies to products that are used in the medical area in th...

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EN 13697

Quantitative Non-Porous Surface Test for the Evaluation of Bactericidal and/or Fungicidal Activity of Chemical Disinfectants Used in Food, Industrial, Domestic and Institution...

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EN 1276

Quantitative Suspension Test for the Evaluation of Bactericidal Activity of Chemical Disinfectants and Antiseptics used in Food, Industrial, Domestic and Institutional Areas T...

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EN 1275

Quantitative Suspension Test for the Evaluation of Basic Fungicidal or Basic Yeasticidal Activity of Chemical Disinfectants and Antiseptics This European Standard applies to a...

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EN 1040

Chemical Disinfectants and Antiseptics- Quantitative Suspension Test for the Evaluation of Basic Bactericidal Activity of Chemical Disinfectants and Antiseptics This European ...

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EN 1650

Quantitative Suspension Test for the Evaluation of Fungicidal Activity of Chemical Disinfectants and Antiseptics Used in Food, Industrial, Domestic and Institutional Areas Thi...

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EP 5.1.3

The European Pharmacopeia describes in General Text 5.1.3, the assay they recommend for testing preservative efficacy. The EP divides products into three tables: 5.1.3-1 - Par...

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ISO Standards

ISO standards are a set of guidelines that ensure quality, safety and efficiency for you products. This is not a complete list of BSLI’s capabilities, connect with our experts...

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ISO 10993-5

Biological Evaluation of Medical Devices This test method describes methods to assess the in-vitro cytotoxicity of medical devices. These methods specify the incubation of cul...

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ISO 11930

The International Organization for Harmonization is designed for cosmetic formulations. Unlike the USP 51 or EP 5.1.3, ISO does not divide products into different categories. ...

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JIS Standards

Japanese Industrial Standards (JIS) are standardized testing methods for submitting your product data for submission in Japan....

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JIS L1902

Determination of Antibacterial Activity of Antibacterial Materials This standard test method evaluates the antibacterial activity of antibacterial finished textile products in...

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OECD

The Organisation for Economic Co-operation and Development (OECD) are globally recognized guidelines for safety testing and assessing the potential effects of chemicals on hum...

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OECD 431

In-Vitro Skin Corrosion: Human Skin Model Test In this method, the test material (solid or liquid) is applied to a three-dimensional human skin model and corrosive materials a...

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OECD 437

Bovine Corneal Opacity and Permeability (BCOP) Test Method for Identifying Ocular Corrosives/Severe Irritants and Substances not Classified as Irritants The Bovine Corneal Opa...

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OECD 439

In-Vitro Skin Irritation: Reconstructed Human Epidermis Test Method This method is based on the reconstructed human epidermis, which closely mimics the properties of the upper...

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OECD 435

In Vitro Membrane Barrier Test Method for Skin Corrosion This method describes an in vitro membrane barrier test method that is used to identify corrosive substances. It utili...

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OECD 492

Reconstructed human Cornea-like Epithelium (RhCE) test method for identifying chemicals not requiring classification and labeling for eye irritation or serious eye damage Thi...

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PCPC

PCPC (formerly referred to as Cosmetic, Toiletry and Fragrance Association or CTFA): The Personal Care Products Council provides guidance for preservative efficacy testing in ...

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Personal Care Products Council (PCPC)

Preservation Testing of Water-Miscible Products Challenge testing a formula with known microorganisms to verify that if the products become contaminated, the preservative syst...

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Services


Clinical Antimicrobial Testing

Efficacy studies are used to validate your products intended purpose, substantiate claims and/or to gain an edge on your competition. Because labeling is regulated by the FDA,...

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Injection Site Protection

Injection sites are a common source of nosocomial infections. Proper pre-treatment and prophylaxis of these sites are important to reducing healthcare costs and improving pati...

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Disinfectants

BioScience Laboratories, Inc. (BSLI) has over twenty years of experience performing standard (AOAC and EN) disinfectant testing methods, including custom-designed efficacy tes...

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Disinfectant and Sanitizer Testing Services

BioScience Laboratories has streamlined our processes, as well as our pricing structure to better meet the expectations of our customers. We now have an accelerated study init...

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Disinfectant Validation

Disinfectant Validation Studies are an FDA requirement to demonstrate the broad-spectrum antimicrobial efficacy of one or more disinfectant products employed for pharmaceutica...

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In-Vitro Efficacy Testing

BioScience Laboratories has twenty three years of experience in conducting clinical & in-vitro studies on antimicrobial products used in food service, healthcare, and jani...

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MIC/MBC Testing

Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) testing define a test material's potency in terms of the concentration at which it will inh...

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Time-Kill Kinetics - Antimicrobial Efficacy Test

Testing Antimicrobial Reduction - Time Kill MethodTime-Kill In Vitro assay tests are referred to as “suspension tests” because a measured volume of the suspension of challenge...

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Zone of Inhibition

This diffusion test is used to evaluate the static/cidal activity of water-soluble, leachable antimicrobial formulations that will diffuse into an nutrient agar medium. Select...

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Antimicrobial Preservative Efficacy Testing

Antimicrobial Effectiveness Tests, or Preservative Effectiveness Tests, are performed to determine the efficacy of the antimicrobial preservatives added to many pharmaceutical...

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In-Vitro Safety Testing

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Bovine Corneal Opacity and Permeability (BCOP)

The Bovine Corneal Opacity and Permeability (BCOP) test is an in-vitro method to evaluate chemicals inducing serious eye damage or serious eye irritation. This test method is ...

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Dermal Irritation Testing

The EpiDerm™ Skin Model uses a culture of normal human-derived epidermal keratinocytes that forms a multi-layered model of the human epidermis. This model is mitotically and m...

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Wound Care

BioScience Laboratories, Inc. has worked with wound dressings for more than 20 years. We offer a way to sell your products for more bottom-line profit to you. We evaluate seve...

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Bandage and Wound Care Absorbency Testing

We possess the equipment and facilities to evaluate the absorbency and vapor permeability of bandage and wound care dressings....

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Wound Healing Evaluations

Evaluations of the rate of cell proliferation, measured as a function of cellular protein expression (e.g., growth factors) in a 3-D model of wound reepithelialization....

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First Aid Wound Management

In-vitro evaluations as described under II-A, and as follows: Screening zone-of-inhibition studies.Studies per methodology prescribed by the FDA: 21 CFR Sections 333 and 369, ...

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In-Vitro Wound Management Evaluations

In-vitro evaluations of antimicrobial properties versus ATCC or clinically isolated strains of bacteria relevant to surgical-, burn-, and catheter-related infections. Time-Kil...

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