Dermal Irritation Testing

Dermal Irritation Testing

The EpiDerm™ Skin Model uses a culture of normal human derived epidermal keratinocytes that forms a multi-layered model of the human epidermidis. This model is mitotically and metabolically active and closely mimics the responses to products exhibited by its in-vivo counterpart (RIPT). 

  • Skin Irritation
  • Dermal Corrosion
  • Percutaneous Absorption
  • Mitotically and metabolically active and closely mimics the responses to products exhibited by its in vivo counterpart

Dermal irritation testing is conducted using the ET-50 method (time of exposure needed for a test article to reduce the viability to 50% of control tissues) and the EpiDerm tissue model.  This model consists of normal (non-cancerous), human cell-derived epidermal keratinocytes cultured to form a multilayered model of the human epidermidis.  The dermal irritation evaluation used at BioScience Laboratories involves applying neat test articles to the EpiDerm tissue model.  This test method closely approximates the responses to product exposure exhibited by its in-vivo counterpart, the Human Repeat-Insult Patch Testing.  Based on the ET-50 and comparison to benchmark materials, the degree of dermal irritancy can be estimated.  An additional benefit of dermal irritation testing is that, in many instances, results obtained using animal-based testing do not correlate well with the actual response seen in human tissue.

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Virology Laboratory

BioScience Laboratories assists clients with new product development, R&D projects, marketing claims, and supporting EPA, FDA, EU, and Health Canada label claims. Combining our virology capabilities with over 23 years of experience in conducting GLP and GCP compliant studies, we can offer a start-to-finish solution. Our virology laboratory personnel are well-trained on the…

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Dermal OECD 431

In-Vitro Skin Corrosion: Human Skin Model Test

In this method, the test material (solid or liquid) is applied to a three-dimensional human skin model and corrosive materials are identified by their ability to produce a decrease in cell viability below defined threshold levels at specified exposure periods. Colored chemicals…

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Dermal OECD 439

In-Vitro Skin Irritation: Reconstructed Human Epidermis Test Method

This method is based on reconstructed human epidermis, which closely mimics the properties of the upper layers of the human skin. Cell viability is measured by enzymatic conversion of the vital dye MTT into a blue formazan salt that is quantitatively…

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Personal Care Products

We serve clients from around the world who contract us to perform investigative studies on a wide range of personal care products. Standard, validated protocols have been developed to substantiate a wide variety of personal care product claims as well as claims for prescription and over-the-counter drug products. Specialized testing for these…

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Cosmetic & Beauty Product Testing

BioScience Laboratories, Inc. (BSLI) offers comprehensive in-vitro and clinical cosmetic testing capabilities. BSLI performs human clinical evaluations performed for safety, efficacy and claims support of cosmetics, raw materials, toiletries, personal care, household and dermal OTC's. We specialize in customized studies to support product claims from moisturization, anti-aging, antiperspirant and acne to…

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Commercial/Professional Products

We have the knowledge base, equipment and experience to test your products for safety and efficacy to meet the global market. Serving such areas as food contact/non-food contact sanitizers and antimicrobial fabrics to name a few. We also offer a wide variety of safety testing in our in-vitro labs to…

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Household Products

BioScience Laboratories, Inc. has the capability to test a wide range of household, non-durable products. From disinfectants and sanitizers to antimicrobial coatings, let BSLI help you with your testing needs. Our vast experience also reaches into materials testing for tensile strength, shear strength, moisture vapor transmission rate, and peel adhesion.…

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