Dermal OECD 431

Dermal OECD 431

In-Vitro Skin Corrosion: Human Skin Model Test

In this method, the test material (solid or liquid) is applied to a three-dimensional human skin model and corrosive materials are identified by their ability to produce a decrease in cell viability below defined threshold levels at specified exposure periods. Colored chemicals may interfere with the assay, so an alternative HPLC procedure can also be used. The main principle of the human skin model assay is that corrosive chemicals can penetrate the stratum corneum by diffusion or erosion, and are cytotoxic to the underlying cell layers.

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BioScience Laboratories assists clients with new product development, R&D projects, marketing claims, and supporting EPA, FDA, EU, and Health Canada label claims. Combining our virology capabilities with over 23 years of experience in conducting GLP and GCP compliant studies, we can offer a start-to-finish solution. Our virology laboratory personnel are well-trained on the…

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