In-Vitro Testing Laboratory | Bioscience Labs

In-Vitro Testing Laboratory

In-Vitro Testing Laboratory

Scientists in our In-Vitro testing labs are well trained on ASTM, AATCC, AOAC, CLSI, and EN standard methods. The efficacy testing services of this laboratory include MIC/MBC, biofilm prevention and removal, time-kill kinetics, clean room disinfectant validation, zone of inhibition and custom efficacy studies for disinfectants, antimicrobials and other products requiring EPA registrations and FDA 510(k) submissions. Studies in our in-vitro lab can also be designed and executed to differentiate existing products within the market and support unique label claims.

BioScience provides a wide scope of in-vitro test evaluation possibilities from one to two microorganism screening evaluations to evaluations using more than 1,500 ATCC strains and clinical isolates. 

Our In-Vitro Laboratory uses tissue models prepared by the company leading the development of alternatives to animal testing methods to perform safety testing on cosmetics, surfacant-based products, pharmaecuticals and chemicals as well as products for personal care, hair care, and household cleaning . These tests include Ocular Irritation, Skin Irritation, Dermal Corrosion, Oral Irritation, and Cytotoxicity. 

Services Include:
Methods
Services

USP 51

ANTIMICROBIAL PRESERVATIVE EFFECTIVENESS TEST (PET) The U.S. Pharmacopeia describes in General Chapter 51, the assay they recommend for testing preservative efficacy. The USP divides products…
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AOAC 965.12

Tuberculocidal Activity of Disinfectants This standard test method recommended by the EPA demonstrates efficacy on hard non-porous surfaces against M. bovis.  BioScience Labs offers this…
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OECD 437

Bovine Corneal Opacity and Permeability (BCOP) Test Method for Identifying Ocular Corrosives/Severe Irritants and Substances not Classified as Irritants The Bovine Corneal Opacity and Permeability…
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ASTM - E2783

Standard Test Method for Assessment of Antimicrobial Activity for Water-Miscible Compounds Using a Time-Kill Procedure This test method measures the changes of a population of…
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AOAC 955.16

Chlorine (available) in Disinfectants; Germicidal Equivalent Concentration  This standard test method provides efficacy data that demonstrates equivalent performance of Test Product equivalent concentrations to sodium…
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EN 13697

Quantitative Non-Porous Surface Test for the Evaluation of Bactericidal and/or Fungicidal Activity of Chemical Disinfectants Used in Food, Industrial, Domestic and Institutional Areas This method…
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EN 13727

Quantitative Suspension Test for the Evaluation of Bactericidal Activity in the Medical Area This European Standard applies to products that are used in the medical…
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ISO 11930

The International Organization for Harmonization is designed for cosmetic formulations. Unlike the USP 51 or EP 5.1.3, ISO does not divide products into different categories.…
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AOAC 955.14, 955.15, and 964.02

Use Dilution Method These standard methods test the efficacy of disinfectants against three standard bacteria on hard surfaces.  These standard tests are used for products…
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EN1650

Quantitative Suspension Test for the Evaluation of Fungicidal activity of Chemical Disinfectants and Antiseptics Used in Food, Industrial, Domestic and Institutional Areas This method describes…
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EN 13624

Quantitative Suspension Test for the Evaluation of Fungicidal Activity of Chemical Disinfectants for Instruments used in the Medical Area This European Standard applies to products…
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OECD 435

In Vitro Membrane Barrier Test Method for Skin Corrosion This method describes an in vitro membrane barrier test method that is used to identify corrosive…
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AOAC 960.09

Germicidal and Detergent Sanitizing Action of Disinfectants Test This standard test method tests the efficacy of food contact sanitizers against S. aureus and E. coli. …
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AOAC 965.13

Disinfectants (Water) for Swimming Pools This standard test method recommended by the EPA provides efficacy data for Test Products designed to disinfect spa and pool…
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OECD 431

In-Vitro Skin Corrosion: Human Skin Model Test In this method, the test material (solid or liquid) is applied to a three-dimensional human skin model and…
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CLSI M07-A10

Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically Susceptibility testing is indicated for any organism that contributes to an infectious process warranting…
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ASTM E2799

MBEC Reactor Protocol BioScience Labs provides services for evaluation of product efficacy in the prevention and/or removal of biofilms using in-vitro techniques.  This method serves…
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OECD 492

Reconstructed human Cornea-like Epithelium (RhCE) test method for identifying chemicals not requiring classification and labelling for eye irritation or serious eye damage  This method utilizes…
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AOAC 966.04

Sporicidal Activity of Disinfectants This standard method tests the efficacy of disinfectants against spore-forming bacteria on hard surface carriers.  This standard test is suitable for…
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EN 1040

Chemical Disinfectants and Antiseptics- Quantitative Suspension Test for the Evaluation of Basic Bactericidal Activity of Chemical Disinfectants and Antiseptics This European Standard applies to active…
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OECD 439

In-Vitro Skin Irritation: Reconstructed Human Epidermis Test Method This method is based on reconstructed human epidermis, which closely mimics the properties of the upper layers…
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ASTM - E2274

Standard Test Method for Evaluation of Laundry Sanitizers and Disinfectants This test method is designed to evaluate sanitizing/ disinfectant laundry detergents/additives for use in top-loading…
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ASTM E2562

CDC Biofilm Reactor Protocol BioScience Labs provides services for evaluation of product efficacy in the prevention and/or removal of biofilms using in-vitro techniques.  This method…
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EP 5.1.3

The European Pharmacopeia describes in General Text 5.1.3, the assay they recommend for testing preservative efficacy. The EP divides products into three tables: 5.1.3-1 -…
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AOAC 955.17

Fungicidal activity of Disinfectants' Using Trichophyton Mentagrophytes This standard test method recommended by the EPA provides efficacy data for Test Products designed as disinfectants with…
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AOAC Germicidal Towelette Test

This standard method evaluates the efficacy of towelette disinfectants according to ASTM E2362-09 based on EPA SOP’s.  BioScience Labs offers this service to provide the…
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EN 1275

Quantitative suspension Test for the Evaluation of Basic Fungicidal or Basic Yeasticidal Activity of Chemical Disinfectants and Antiseptics This European Standard applies to active substances…
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ISO 10993-5

Biological Evaluation of Medical Devices This test method describes methods to assess the in-vitro cytotoxicity of medical devices. These methods specify the incubation of cultured…
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ASTM - E2406

Standard Test Method for Evaluation of Laundry Sanitizers and Disinfectants for Use in High Efficiency Washing Operations This test method is designed to evaluate sanitizing/…
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ASTM E2871

Single Tube Method BioScience Labs provides services for evaluation of product efficacy in the prevention and/or removal of biofilms using in-vitro techniques. This method is typically…
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ASTM - E2197

Standard Quantitative Disk Carrier Test Method for Determining Bactericidal, Virucidal, Fungicidal, Mycobactericidal, and Sporicidal Activities of Chemicals This test method is designed to evaluate the…
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Personal Care Products Council (PCPC)

Preservation Testing of Water-Miscible Products Challenge testing a formula with known microorganisms to verify that if the products become contaminated, the preservative system is sufficient to…
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AOAC 961.02

Germicidal Spray Products as Disinfectants This standard test method recommended by the EPA provides efficacy data for Test Products designed as germicidal spray products.  The method…
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ASTM - E2149

Standard Test Method for Determining the Antimicrobial Activity of Antimicrobial Agents Under Dynamic Contact Conditions This test method is designed to evaluate the antimicrobial activity…
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EN 14348

Quantitative Suspension Test for the Evaluation of Mycobactericidal Activity of Chemical Disinfectants in the Medical Area Including Instrument Disinfectants  This document specifies a test method…
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ASTM E2647

Drip Flow Reactor Protocol BioScience Labs provides services for evaluation of product efficacy in the prevention and/or removal of biofilms using in-vitro techniques. This method represents…
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ASTM - E2362

Standard Practice for Evaluation of Pre-saturated or Impregnated Towelettes for Hard Surface Disinfection This test method may be used to determine if a pre-saturated or impregnated…
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ASTM - E640

Standard Test Method for Preservatives in Water-Containing Cosmetics This test method covers the determination of the suitability of preservatives for use in cosmetic formulations. It…
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ASTM- E1153

Standard Test Method for Efficacy of Sanitizers Recommended for Inanimate Non-Food Contact Surfaces This test method is used to evaluate the antimicrobial efficacy of sanitizers…
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EN1276

Quantitative Suspension Test for the Evaluation of Bactericidal Activity of Chemical Disinfectants and Antiseptics used in Food, Industrial, Domestic and Institutional Areas This European Standard…
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ASTM- E1054

Standard Test Method for Evaluation of Inactivators of Antimicrobial Agents The effectiveness of antimicrobial agents incorporated into disinfectants, sanitizers, and antiseptics is measured by their…
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ASTM - E2280

Standard Test Method for Determining the Activity of Incorporated Antimicrobial Agent(s) in Polymeric or Hydrophobic Materials This test method is designed to evaluate (quantitatively) the…
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AATCC - 100

Antimicrobial Finishes on Textile Materials This test method provides a quantitative procedure for the evaluation of the degree of antibacterial activity. Assessment of antibacterial finishes…
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JIS L1902

Determination of Antibacterial Activity of Antibacterial Materials This standard test method evaluates the antibacterial activity of antibacterial finished textile products including woven and non-woven material. …
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Antimicrobial Preservative Efficacy Testing

Antimicrobial Effectiveness Tests, or Preservative Effectiveness Tests, are performed to determine the efficacy of the antimicrobial preservatives added to many pharmaceutical and cosmetic products to…
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Dermal Irritation Testing

The EpiDerm™ Skin Model uses a culture of normal human derived epidermal keratinocytes that forms a multi-layered model of the human epidermidis. This model is…
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In-Vitro Wound Management Evaluations

In-vitro evaluations of antimicrobial properties versus ATCC or clinically isolated strains of bacteria relevant to surgical-, burn-, and catheter-related infections. Time-Kill Kinetic studies (planktonic and…
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Bovine Corneal Opacity and Permeability (BCOP)

The Bovine Corneal Opacity and Permeability (BCOP) test is an In-Vitro method to evaluate chemicals inducing serious eye damage or serious eye irritation.  This test…
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Zone of Inhibition

This diffusion test is used to evaluate the -static/-cidal activity of water-soluble, leachable antimicrobial formulations that will diffuse into an nutrient agar medium.  Selected challenge species are…
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First Aid Wound Management

In-vitro evaluations as described under II-A, and as follows: Screening zone-of-inhibition studies. Studies per methodology prescribed by the FDA: 21 CFR Sections 333 and 369,…
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Time-Kill Kinetics - Antimicrobial Efficacy Test

Time-Kill In Vitro assay tests are referred to as “suspension tests” because a measured volume of the suspension of challenge bacteria or fungi is transferred into a…
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MIC/MBC Testing

Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) testing define a test material's potency in terms of the concentration at which it will inhibit…
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Disinfectant and Sanitizer Testing Services

BioScience Laboratories has streamlined our processes, as well as our pricing structure to better meet the expectations of our customers. We now have an accelerated…
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Disinfectant Validation

Disinfectant Validation Studies are an FDA requirement to demonstrate the broad-spectrum antimicrobial efficacy of one or more disinfectant  products employed for pharmaceutical production area qualification…
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Injection Site Protection

Injection sites are a common source of nosocomial infections. Proper pre-treatment and prophylaxis of these sites is important to reducing healthcare costs and improving patient well-being.…
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Wound Healing Evaluations

Evaluations of rate of cell proliferation, measured as a function of cellular protein expression (e.g., growth factors) in a 3-D model of wound reepitheliazation.
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Bandage and Wound Care Absorbency Testing

We possess the equipment and facilities to evaluate the absorbency and vapor permeability of bandage and wound care dressings. 
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